APRIL
4, 2008 |
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| Time |
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Auditorium Bachelet |
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| 6.00 p.m. |
|
Opening Ceremony |
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| 6.15 p.m. |
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J. Van der Meer (Nijmegen):
Fever of unknown origin in post-genomic era |
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| 6.45 p.m. |
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D. Kastner (Bethesda):
The expanding autoinflammatory galaxy
|
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| 7.15 p.m. |
|
Welcome Cocktail and Concert |
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APRIL 5, 2008 |
| Pathways of the Innate Immunity |
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|
1st Session |
| 8.30 a.m. |
|
D. Golenbock (Worcester):
Toll-like receptors (TLRs) |
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| 8.55 a.m. |
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M.E. Bianchi (Milan):
Damps, PAMPs and alarmins |
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| 9.20 a.m. |
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F. Martinon (Boston):
The inflammasome |
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| 9.45 a.m. |
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A. Rubartelli (Genoa):
Mechanism of IL-1 secretion |
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| 10.10 a.m. |
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C. Dinarello (Denver):
Caspase-activated cytokines |
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| 10.35-11.05 a.m. |
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Discussion |
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| 11.05-11.30 a.m. |
|
Coffee break |
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|
2nd Session |
| 11.30 a.m. |
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R. Flavell (New Haven):
Innate immunity driving adaptive immunity |
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| 11.55 a.m. |
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M. McDermott (Leeds):
Inflammasome and Autoimmunity diseases |
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| 12.20 p.m. |
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R. Slim (Montreal):
NALP7 and hydatidiform moles |
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| 12.45-1.00 p.m. |
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Discussion |
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| 1.00 p.m.-3 p.m. |
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Lunch and poster viewing |
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| NALP related diseases |
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|
1st session |
| 3.00 p.m. |
|
H. Hoffman (San Diego):
FCAS and MWS |
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| 3.20 p.m. |
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R. Goldbach-Mansky (Bethesda):
CINCA/NOMID clinical and therapeutic studies |
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Oral Communication |
| 3.40 p.m. |
|
I. Jeru (Paris):
Mutations in NALP12 cause periodic fever syndromes |
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| 3.50 p.m.-4.00 p.m. |
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Discussion |
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|
2nd session |
| 4.00 p.m. |
|
Summing-up of Poster session |
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Oral Communications |
| 4.15 p.m. |
|
J.E. Balow Jr (Bethesda):
Microarray-based gene expression studies of systemic inflammation in patients with cryopyrin-associated periodic syndromes (CAPS) |
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| 4.25 p.m. |
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A. Piccini (Genoa):
ATP released following activation of various pathogen-sensing receptors autocrinally induces IL-1beta and IL-18 secretion by monocytes |
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| 4.35 p.m. |
|
S. D. Brydges (Bethesda):
Initial Characterization of a Mouse Model of Cryopyrinopathy |
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| 4.45 p.m. |
|
J. Anderson (San Diego):
Characterization of the human CIAS1 promoter |
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| 4.55 p.m. - 5.30 p.m. |
|
Coffee break |
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| 5.30 p.m.-6.30 p.m. |
|
The Thief Market (Interactive clinical cases) E. Ben-Chetrit (Jerusalem) |
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APRIL 6, 2008 |
| From MEFV to Familial Mediterranean Fever |
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|
1st session |
| 8.15 a.m. |
|
J. Chae (Bethesda):
Pyrin knock down and know out mice |
| |
| 8.35 a.m. |
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I. Touitou (Montpellier):
Interpretation of genetic testing and quality control for hereditary fevers |
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| 8.55 a.m. |
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S. Ozen (Ankara):
What about the heterozygotes? |
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| 9.15-9.30 a.m. |
|
Discussion |
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| 9.30-10.00 a.m. |
|
Coffee break |
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|
2nd session |
| 10.00 a.m. |
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R. Manna (Rome):
Clinical features of FMF and diagnosis |
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| 10.20 a.m. |
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A. Livneh (Tel Hashomer):
Diseases management |
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| 10.40 a.m. |
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H. Ozdogan (Istanbul):
Therapeutic advances |
| 11.00-11.15 a.m. |
|
Discussion |
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Oral communications |
| 11.15 a.m. |
|
M. Booty (Bethesda):
Novel insights into the inheritance and diagnosis of familial Mediterranean fever (FMF) |
| |
| 11.25 a.m. |
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S. Stojanov (Bethesda):
Altered Development and Function of CD11c+ Cells in Pyrin-Null Mice |
| |
| 11.35 a.m. |
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T. Kallinich (Berlin):
S-100A12 as a sensitive marker for the detection of inflammation in
children and adolescents with Familial Mediterranean Fever |
| |
| 11.45 a.m. |
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N. Bradman (London):
Incidence of MEFV exon 10 and exon 2 polymorphisms in multiple
Asian, European and African countries and a novel test for geographically
restricted positive selection pressure |
| |
| 11.55 a.m. |
|
G. Wood (Bethesda):
RNA interference of MEFV in THP.1 cells reveals a role for endogenous
pyrin in Toll-like receptor signaling (TLR) that is mediated by the transcription factor IRF2 |
| |
| 12.05 p.m. |
|
A. Gul (Bethesda):
The MEFV Gene 3'-UTR Alu Repeat Polymorphisms in Patients with
Familial Mediterranean Fever |
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| 12.15-2.00 p.m. |
|
Lunch and poster viewing |
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|
3rd Session |
| 2.00 p.m. |
|
Summing-up of Poster session |
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Oral communications |
| 2.15 p.m. |
|
M. La Regina (Rome):
Trends in colchicine treatment in familial mediterranean fever (FMF) |
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| 2.25 p.m. |
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E. Pras (Tel Hashomer):
Clinical Disease among FMF Heterozygotes |
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| 2.35 p.m. |
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N. Aktay Ayaz (Ankara):
Differences In The Severity Of The Phenotype Of Children and Adolescents
With Familial Mediterranean Fever Residing In Turkey and Germany |
| |
| 2.45 p.m. |
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E. Verrecchia (Rome):
Role of small intestinal bacterial overgrowth in colchicine non-responders |
| |
| 2.55 p.m. |
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N. Colburn (Bethesda):
Dissecting Inflammatory and Chemotactic Pathways in Familial Mediterrean Fever |
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| From Mevalonate kinase deficency to Periodic Fever |
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| 3.05 p.m. |
|
J. Frenkel (Utrecht):
The missing link |
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| 3.25 p.m. |
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J. Drenth (Njimegen):
Clinical aspects |
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| 3.45-3.55 p.m. |
|
Discussion |
| |
| 3.55 p.m. |
|
Summing-up of Poster session |
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Oral communications |
| 4.10 p.m. |
|
J. Frenkel (Utrecht):
Impaired isoprenoid biosynthesis induces caspase-1 activation in a Rac1/PI3kinase/PKB
dependent fashion: implications for the Hyper IgD syndrome. |
| |
| 4.20 p.m. |
|
J. Ch. van der Hilst (Njimegen):
Follow-up, clinical features, and quality of life in 103 patients with
HyperImmunoglubulin D syndrome |
| |
| 4.30 p.m. |
|
S. Federici (Genoa):
Validation of a diagnostic score for molecular analysis of hereditary
autoinflammatory syndromes in children with periodic fever. |
| |
| 4.40 p.m. |
|
F. Yalcinkaya (Ankara):
A new set of criteria for the diagnosis of familial mediterranean fever
in childhood |
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| 4.50-5.20 p.m. |
|
Coffee Break |
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| 5.45 p.m. |
|
Departure by bus for visit to Musei Capitolini |
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| 8.15 p.m. |
|
Social Dinner - Terrazza Caffarelli |
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APRIL 7, 2008 |
| New insights for TRAPS |
| |
| 8.30 a.m. |
|
A. Simon (Njimegen/Bethesda):
Pathogenic consequences of TNFR trafficking abnormalities |
| |
| 8.50 a.m. |
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I. Todd (Nottingham):
Mutant TNF receptor in transfection systems |
| |
| 9.10 a.m. |
|
M. Gattorno (Genoa):
Lessons from TRAPS patients |
| |
| 9.30-9.45 a.m. |
|
Discussion |
| |
| 9:45 a.m. |
|
Summing-up of Poster session |
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|
Oral communications |
| 10:00 a.m. |
|
J. G. Ryan (Bethesda):
Identification and analysis of gene-expression signatures in peripheral
blood leukocytes of patients with TRAPS |
| |
| 10:10 a.m. |
|
B. Nedjai (London):
Abnormal TNFR1 cell surface expression and NF-KappaB activation in TNFR1-associated
periodic fever syndrome (TRAPS) |
| |
| 10.20-10.50 a.m. |
|
Coffee Break |
| |
| The expanding spectrum of autoinflammatory diseases |
| |
| |
|
1st Session |
| 10:50 a.m. |
|
D. Kastner (Bethesda):
PAPA Syndrome |
| |
| 11:10 a.m. |
|
H. El-Shanti (Iowa):
Chronic Recurrent Multifocal Osteomyelitis |
| |
| 11:30 a.m. |
|
A. Martini (Genoa):
Systemic-Onset Juvenile Idiopathic Arthritis |
| |
| 11:50 a.m. |
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M. Hofer (Lausanne):
PFAPA |
| |
| 12:10 p.m. |
|
A. Brucato (Bergamo):
Recurrent Pericarditis |
| |
| 12.30-1.00 p.m. |
|
Discussion |
| |
| 1.00-2.45p.m. |
|
Lunch and poster viewing |
| |
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|
2nd Session |
| 2.45 p.m. |
|
A. Gul (Istanbul):
Behçet Syndrome |
| |
| 3.05 p.m. |
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I. Koné-Paut (Paris):
Behçet Syndrome in children |
| |
| 3.25 p.m. |
|
A. Simon (Njimegen):
Schnitzler Syndrome |
| |
| 3.45 p.m. |
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C. Wouters (Leuven):
Blau Syndrome |
| |
| 4.05 p.m. |
|
M. Chamaillard (Lille):
NOD2 in inflammatory bowel diseases and other granulomatous diseases |
| |
| 4.25-4.45 p.m. |
|
Discussion |
| |
| 4.45-5.15 p.m. |
|
Coffee Break |
| |
| 5.15 p.m. |
|
Summing-up of Poster session |
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|
Oral Communications |
| 5.30 p.m. |
|
A. Rösen-Wolff (Dresden):
Mutated, structurally altered caspase-1 with decreased enzymatic and
increased RIP2 mediated inflammatory activity leads to a new type of
periodic fever (ICE fever) |
| |
| 5.40 p.m. |
|
P. Ferguson (Iowa City):
A Mutation in Exon 8 of the Cherubism Gene is Associated with a Novel Autoinflammatory Phenotype that Affects the Skin and the Bone |
| |
| 5.50 p.m. |
|
N. Kanazawa (Wakayama):
Familial Japanese fever (Nakajo-Nishimura syndrome): a novel hereditary
periodic fever with partial lipodystrophy and a search for LPIN gene
mutations |
| |
| 6.00 p.m. |
|
C. LI (Beijing):
Clinical phenotype and CARD15 gene mutation with Blau Syndrome in Chinese children and their parents |
| |
| 6.10 p.m. |
|
M.FJ André (Clermont-Ferrand):
Longer form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients |
| |
| 6.20 p.m. |
|
R. Priori (Rome):
Systemic and tissutal IL-18 expression in adult onset Still's disease |
| |
| 6.30 p.m. |
|
M. Gattorno (Genoa):
The pattern of response to anti IL-1 treatment distinguish two subset of patients with systemic onset juvenile idiopathic arthritis (SoJIA) |
| |
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APRIL 8, 2008 |
| New Insights in Amyloidosis |
| |
| |
|
1st Session |
| 8.30 a.m. |
|
P. Hawkins (London):
Amyloidosis in autoinflammatory diseases |
| |
| 8.50 a.m. |
|
G. Merlini (Pavia):
New therapy for Amyloidosis |
| |
| 9.10-9.20 a.m. |
|
Discussion |
| |
| 9.20 a.m. |
|
Summing-up of Poster session |
| |
| 9.30 a.m. |
|
B. Balci-Peynircioglu (Ankara):
Expression of ASC in renal tissues of FMF patients with amyloidosis; postulating a role for ASC in AA type amyloid deposition |
| |
| 9.40 a.m. |
|
G. Hatemi (Istanbul):
Tumor Necrosis Factor alpha Antagonists in the Treatment of Secondary Amyloidosis |
| |
| 9.50-10.20 a.m. |
|
Coffee Break |
| |
| Novel Treatments in autoinflammatory diseases |
| |
| 10.20 a.m. |
|
O. Della Casa Alberighi (Genoa):
Drug development in rare diseases |
| |
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|
Oral Communications |
| 10.40 a.m. |
|
H. Hoffman (San Diego):
Rilonacept in Patients with Cryopyrin-Associated Periodic Syndromes
(CAPS): The Durability of Response over 48 weeks |
| |
| 10.50 a.m. |
|
K. JB Kuemmerle-Deschner (Tuebingen):
Long-lasting response to ACZ885 (a new human IgG1 anti-IL-1_
monoclonal antibody) in patients with Muckle-Wells Syndrome (MWS) |
| |
| 11.00 a.m. |
|
H. Lachmann (London):
Treatment of cryopyrin associated periodic fever syndrome with
a fully human anti-IL-1beta monoclonal antibody (ACZ885): results from a subcutaneous administration study. |
| |
| 11.10 a.m. |
|
R. Torres (Tarrytown):
mIL-1 Trap Reduces Pain and Inflammation in Animal Models of Gout |
| |
| 11.20 a.m. |
|
A. Radin (Tarrytown):
Placebo-controlled Pilot Study of Rilonacept (IL-1 Trap), A Long Acting
IL-1 Inhibitor, In Refractory Chronic Active Gouty Arthritis |
| |
| 11.30 a.m. |
|
M. D. Casas González (Madrid):
Safety and efficacy of Infliximab and Rituximab in patients
with refractory Behçet disease |
| |
| 11.40 a.m. |
|
P. Miettunen (Calgary):
Effective Treatment with IV Pamidronate in Chronic Recurrent
Multifocal Osteomyelitis( CRMO)-Resolution of Pain, Normalization of Radiologic Abnormalities, and Improvement of Elevated Urine-N-Telopept |
| |
| 11.50-1.00 p.m. |
|
Future projects and conclusions |
